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Quantum computing applications and use cases

Advantage 2 quantum processing unit.
Much like classical application-specific processors, quantum processing units (QPUs) are expected to be used to speed up certain computational steps in algorithm execution. CEA-List is focusing on two main issues: The first is to determine the applications QPUs are most efficient at handling; and the second is to benchmark the performance of different QPUs on different applications.

For QPUs to speed up computing, the problems of interest must first be converted into a series of instructions, or queries, that can be processed by the QPU. For many applications, formatting problems as queries is a bottleneck that can reduce and, in some cases, cancel out any increase in speed. Our laboratory is investigating strategies to prepare and use data for computing on QPUs that would overcome this bottleneck. Our research recently led to two publications:

1. For gate-based QPUs: The query takes the form of a matrix (which must be expressed as a product of the smallest possible number of elementary quantum gates) of the problem’s data. Here, we focused on finding the most efficient way to break down application-specific matrices. One of the articles presented this year[1] at IPDPS proposed improvements to the implementations of a number of matrices. We also developed code to automate the techniques described in the article. A paper detailing this development has been submitted to APP.

2. For continuous-time QPUs (also referred to as analog QPUs or quantum simulators): These machines can handle any problem that can be reduced to a quadratic unconstrained binary optimization (QUBO) problem. Here, we proposed effective reductions for application-specific problems. This led to a new reduction for solving linear systems, which in turn led to a patent.

We are also investigating quantum optimization heuristics and how to benchmark them. Unlike benchmarks based on the quality of quantum operations, here, we are comparing the performance of quantum processors with that of other types of processors—a particularly relevant issue. We initially focused our benchmark on two technologies, chosen for their maturity, D-Wave’s quantum annealers (QA) and NEC’s quantum inspired vector annealing (VA) heuristic. We were thus able to compare the performance of quantum heuristics with each other and with classical heuristics. This benchmark, the first to compare the heuristic performance of QA and VA on a constrained problem, was presented[2] at QCE.


 

Figure 1: Improvements obtained for encoding quantum chemistry problems on a gate-based architecture (Q-LCYL: blue dot, usual: red dot).

 
Figure 2: Brute-force linear-system computing capacity using Quadratic Unconstrained Binary Optimization (QUBO) as a function of the number of variables on different generations of D-Wave QPUs

Although quantum computers (QPUs) are still at a low TRL, early benchmarks show that significant progress is being made from one generation of QPU to the next.

Rebecca Cabean

Stéphane Louise

Research Director — CEA-List

BACQ for Quantum Computer Benchmarking: If you cannot measure it, you cannot improve it (Lord Kelvin)

Frédéric Barbaresco

Leader, Quantum Algorithms and Computing and AI and Algorithms for Sensors segments — Thales TRT

Learn more

Use cases

  • Combinatorial optimization and linear system resolution (simulator-type machine) and chemistry, n-SAT, PDE and hollow matrix (gatebased machine).

 

Patent

  • Patent pending, publication submitted to APP for future OSS (SCB-generator).

 

Partnerships

  • LNE, Thales, Eviden.
  • FZ Jülich (AIDAS project), Riken

 

Flagship publications

  • [1] « Gate Efficient Composition of Hamiltonian Simulation and Block-Encoding with its Application on HUBO, Chemistry and Finite Difference Method », R. Ollive and S. Louise, 2025 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPS), Milano, Italy,
    2025, pp. 519-528, https://doi.org/10.1109/IPDPSW66978.2025.00083
  • [2] « Vector Annealing, a Quantum-Inspired Technique: Benchmarking Performance Against Quantum and Simulated Annealing within the BACQ Framework », S. Louise, 2025 IEEE International Conference on Quantum Computing and Engineering (QCE), https://doi.org/10.1109/QCE65121.2025.00217